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The U.S. Consumer Product Safety Commission (CPSC) has issued the final rule prohibiting phthalates in children’s toys and child care articles on October 27, 2017.

After it was determined that they cause harmful effects on male reproductive development, the following five phthalates are now restricted: DINP, DPENP, DHEXP, DCHP, and DIBP.

Additionally, the Consumer Product Safety Improvement Act of 2008 (CPSIA) permanently banned three phthalates, DEHP, DBP, and BBP, from use in children’s toys and child care articles at concentrations of more than 0.1 percent. Therefore, this ruling brings the total number of phthalates that are restricted from use in these products at this concentration to eight.

Also of note, this rule removes the interim prohibition regarding and DNOP and DIDP, as the CPSC ruled that these two phthalates do not adversely impact male reproductive development.

The rule will take effect on April 25, 2018.